Association of leptin gene (rs 7799039) polymorphism and colorectal cancer

Introduction: Studies show polymorphism in leptin gene cause increase in level of leptin hormone and increased level of leptin hormon is associated with abosity, insulin resistance and increased risk of colorectal cancer. The aim of this study was to assess the incidence of leptin gene polymorphism rs 7799039 in Tehran and to investigate the influence of this polymorphism in increased risk of colorectal cancer. Methods: In this case-control study, genotyping of the leptin gene were determined in series of 108 colorectal cancer patients and 108 controls by using polymerase chain reaction and restriction fragment length polymorphism genotyping assays (PCR-RFLP).The statistical analysis was done with SPSS 16. Results: The frequency of A allele in patient group and control group were 52.8% and 62.5%, respectively. In this study allele frequency showed significant deference between patient group and control group (P=0.04). In patient group frequency of GG, GA, AA for leptin gene were 19.4%, 55.6% and 25%, respectively and in control were 38%, 49.1% and 13%. Conclusion: These findings suggest that polymorphism Leptin rs 7799039, is associated with decreased risk of CRC